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Aspect Results of Paxil to Be Conscious of — Talkspace

Paxil (paroxetine) is an antidepressant that’s FDA-approved to deal with a number of psychological well being situations. Paxil is in a category of medication known as selective serotonin reuptake inhibitors (SSRIs), which alter serotonin ranges within the mind to enhance temper.  

Paxil is accredited to deal with:

  • Main depressive dysfunction (MDD) 
  • Generalized anxiousness dysfunction
  • Panic dysfunction 
  • Social anxiousness dysfunction 
  • Obsessive-compulsive dysfunction (OCD) 
  • Premenstrual dysphoric dysfunction (PMDD) 
  • Publish-traumatic stress dysfunction (PTSD)

Off-label (that means it hasn’t been FDA-approved to deal with however has been discovered efficient), Paxil will be prescribed to deal with OCD in youngsters and irritable bowel syndrome.

Analysis reveals that Paxil is among the most potent SSRIs in the marketplace. Whereas it may possibly successfully deal with a number of psychological well being situations, it’s vital to notice that like most medicines, it additionally has unintended effects. In reality, Paxil may need extra unintended effects than another SSRIs. Earlier than you’re taking Paxil (or any medicine), it’s vital to speak to your physician about potential dangers you ought to be conscious of.

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Being aware of potential penalties is important — proceed studying to be taught in regards to the varied unintended effects of Paxil it’s best to learn about earlier than beginning remedy.

Frequent Aspect Results of Paxil

Many unintended effects of Paxil are delicate and subside as your physique adjusts to the medicine. 

Uncomfortable side effects of Paxil can embrace:

  • Nausea
  • Weak spot
  • Drowsiness 
  • Weak spot 
  • Sexual dysfunction
  • Threat of bleeding
  • Weight achieve


Nausea is among the unintended effects Paxil could cause. Nausea can differ in depth, however sometimes subsides inside a number of days or perhaps weeks. When you expertise nausea whereas taking Paxil, you may wish to attempt consuming smaller meals extra steadily all through the day or taking your medicine with/with out meals.  

Sleeping issues

Sleeping issues are one other frequent facet impact related to taking Paxil. This might imply experiencing problem falling asleep or waking up unexpectedly throughout the evening. When you’re having points falling or staying asleep currently, attempt going to mattress on the similar time every evening, avoiding caffeine late within the day, and limiting your use of electronics earlier than bedtime.


In line with some analysis, Paxil use might trigger extra drowsiness than different antidepressants. Nevertheless, this typically subsides when you grow to be accustomed to Paxil’s results in your physique.

Weak spot 

Weak spot is one other facet impact that Paxil customers expertise. This, too, will seemingly resolve as you grow to be used to the drugs. If the fatigue turns into an excessive amount of, your physician may wish to take into account speaking about decreasing your dose so that you don’t really feel overwhelmed all through your day.  

Sexual dysfunction

Sexual dysfunction is an unlucky risk when utilizing SSRIs like Paxil. Some analysis suggests Paxil may need the highest price of sexual dysfunction of all of the medication on this class. It’s because Paxil impacts hormones liable for libido, thus resulting in a diminished need for intercourse and different points like delayed ejaculation.

Threat of bleeding

There’s an elevated threat of bleeding when taking SSRIs comparable to Paxil. That stated, this isn’t essentially one thing it’s essential fear about except you’ve different threat components for bleeding.

Weight achieve

Weight achieve is mostly related to Paxil greater than different SSRIs. How a lot you may achieve relies upon closely upon components like life-style decisions, physique chemistry, and weight earlier than beginning Paxil. Study extra about Paxil weight achieve for extra data.

“Decreased sexual need, delayed ejaculation, nausea, diarrhea, and constipation are frequent unintended effects. Please attain out to your physician in the event that they worsen.”

Talkspace psychiatrist Dr. Dion Metzger

Critical Aspect Results of Paxil

Paxil might assist deal with melancholy and anxiousness, however it may possibly additionally result in extreme antagonistic reactions.

Serotonin syndrome

Extra serotonin within the physique could cause a severe and doubtlessly life-threatening situation known as serotonin syndrome. Serotonin syndrome is a possible facet impact that’s extra frequent in individuals who take greater doses of Paxil. 

Signs embrace agitation, confusion, sweating, muscle twitching and spasms, fever, and elevated coronary heart price. If in case you have any signs of serotonin syndrome whereas on Paxil — or some other SSRI antidepressant — get medical assist instantly.  

Antidepressant Discontinuation Syndrome

When stopping Paxil all of the sudden or decreasing the dosage too shortly, it may possibly result in what’s referred to as antidepressant discontinuation syndrome. This happens when your mind can’t modify shortly sufficient to decrease serotonin ranges. 

Frequent indicators might contain feeling queasy, lightheadedness, exhaustion, and flu-like sensations comparable to aches and chills. In some instances, there may additionally be vivid goals or nightmares that would last as long as a number of weeks after stopping the medicine abruptly. To keep away from one of these response, it’s greatest to slowly scale back your dose over time with steerage out of your physician slightly than quitting chilly turkey by yourself.

Threat of suicidal ideas and behaviors

It’s important that healthcare suppliers intently monitor folks taking Paxil long-term, as the chance of suicidal ideas and behaviors might happen in uncommon instances. Report any agitation, restlessness, irritability, hostility, aggression, or impulsivity — significantly in case you’re having suicidal ideas — so you’ll be able to obtain rapid consideration.

How Lengthy Do Paxil Aspect Results Final?

When utilizing Paxil, first-week unintended effects will be worse for some folks. Uncomfortable side effects can differ in length and severity relying on the person. Many individuals might expertise some degree of antagonistic reactions for as much as a month after starting the medicine. After this era, it’s frequent for signs to subside. In very uncommon cases, unintended effects can last more than 4 weeks.

“Ready for unintended effects to resolve after 1 – 2 weeks is really useful. This works for gastrointestinal unintended effects comparable to nausea, diarrhea, and constipation. Sexual unintended effects might not resolve with time. Talk along with your physician if in case you have considerations.”

Talkspace psychiatrist Dr. Dion Metzger

Lengthy-Time period Aspect Results of Paxil

The Nationwide Alliance on Psychological Sickness (NAMI) notes there usually aren’t any severe, frequent long-term unintended effects of Paxil it’s essential be involved with, so long as you employ the medicine as directed. 

Methods to Handle Paxil Aspect Results

Be conscious of the potential repercussions when using Paxil. Addressing the doable unintended effects might help make sure you achieve most profit from the prescription drug. Listed here are some ideas for managing Paxil unintended effects:

  • Begin with a low dose and step by step enhance as wanted — Beginning at a decrease dose might scale back the chance of experiencing particular unintended effects like nausea or complications. Focus on along with your physician the very best dosage to your signs. 
  • Take with meals — Taking Paxil with meals might scale back abdomen upset or different digestive points.
  • Keep hydrated — Ingesting loads of fluids all through the day might help decrease dizziness and lightheadedness brought on by Paxil use.
  • Keep away from alcohol — Alcohol consumption ought to usually be averted whereas on any kind of antidepressant medicine, together with Paxil, as it may possibly intrude with its effectiveness and trigger undesirable reactions in some folks.
  • Train frequently — Common train has constructive advantages on psychological well being. Be certain that to not overexert your self throughout exercises in case you really feel drained or weak as a consequence of medicine utilization.
  • Monitor temper modifications intently — If experiencing any sudden modifications in temper whereas taking Paxil, contact your physician instantly to allow them to present medical recommendation and might modify your dosage if needed or suggest different remedy choices.

If unintended effects don’t disappear, discuss to a health care provider earlier than stopping Paxil medicine. Stopping all of the sudden can lead to Paxil withdrawal signs.

See If Paxil Is Proper for You with Talkspace Psychiatry

Regardless of its effectiveness in treating psychological well being situations, Paxil could cause antagonistic results that must be thought of earlier than utilization. Talkspace Psychiatry gives a web based platform for folks desirous to discover if Paxil is true for them. Join with licensed psychiatrists and psychological well being care suppliers who focus on psychological healthcare and medicine administration.

Talkspace gives complete assessments of every affected person’s medical historical past and present signs to find out whether or not or not Paxil can be match for his or her wants. In the event that they do discover it match, they might prescribe you Paxil on-line as a part of your remedy plan. Get began with Talkspace as we speak. 


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  4. Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction related to antidepressant brokers: a potential multicenter research of 1022 outpatients. J Clin Psychiatry. 62(3):10-21. Accessed March 26, 2023.
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  6. Paroxetine (paxil). NAMI. being-Drugs/Sorts-of-Treatment/paroxetine-(paxil). Accessed March 26, 2023. 

Talkspace articles are written by skilled psychological health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our crew of medical consultants (therapists and psychiatrists of assorted specialties) to make sure content material is correct and on par with present business requirements.

Our purpose at Talkspace is to supply essentially the most up-to-date, precious, and goal data on psychological health-related subjects with the intention to assist readers make knowledgeable selections.

Articles comprise trusted third-party sources which are both immediately linked to within the textual content or listed on the backside to take readers on to the supply.



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